53 proteins change in abundance with age.

<p>A. 53 proteins significantly change in abundance with age by rank-product analysis across three biological replicates (10% FDR). Shown is the log₂ fold change in protein abundance between day 4 and day 13 for the proteins that significantly change. 40 proteins increase abundance with age (yellow), and 13 decrease (blue). B. Proteins that decrease abundance with age are encoded by RNAs that also decrease with age, but there is little correlation between RNA and protein abundance change for proteins that increase abundance with age. The scatterplot shows the log₂ ratio of old/young protein expression on the x-axis and the log₂ ratio of old/young RNA expression on the y-axis (microarray expression data from [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005725#pgen.1005725.ref007" target="_blank">7</a>]). Each point is a protein that significantly changes in abundance with age and was also covered on the microarray (32 of 40 proteins that increase and 9 of 13 that decrease abundance with age).