<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice weekly for 8 weeks (marked “Treatment”). At the indicated time points woodchucks were bled and serum was used to analyze levels of liver enzymes. Values were normalized to individual baseline at day 0 and are given in %. n = 5 / group. Dotted lines: 100% or 50% level. (A). Group means of AST concentration +/- SEM. (B) Group means of GGT concentration +/- SEM.</p
<p>Summary of WHcAg-specific (A) and WHsAg-specific (B) degranulation responses evaluated by CD107a ...
<p>(A) Plasma sAg, (B) viral loads, and (C) eAg in animals receiving ETV plus isotype control antibo...
BACKGROUND/AIMS: Immunotherapy of patients chronically-infected with hepatitis B virus (HBV) may hav...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>Two groups of 5 woodchucks each were treated once daily, orally either with SB 9200 (30 mg/kg/day...
<p>At 66 months post-injection with 100 or 10<sup>10</sup> virions of WHV/tm3 (see <a href="http://w...
<p>Chronic WHV carrier woodchucks were dosed three times a week (TIW) for 15 weeks with placebo, or ...
<p>Changes in serum WHV DNA (top panels) and WHsAg levels (bottom panels) relative to T<sub>0</sub> ...
AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense...
<p>N/A: not applicable.</p><p><sup>a</sup>Treatment response groups were defined as follows: R, resp...
<p>Serum harvested from early and late infected pups demonstrates significantly higher concentration...
International audienceApolipoprotein A-I (ApoA-I) is the major protein component of high density lip...
<p>(A) Group geometric mean viral loads in acutely infected woodchucks treated with αPD-L1 at 1 or 1...
<p>Change in serum (a) WHsAg and (b) WHV DNA relative to week -3 (pre-treatment baseline). Circles i...
<p>Summary of WHcAg-specific (A) and WHsAg-specific (B) degranulation responses evaluated by CD107a ...
<p>(A) Plasma sAg, (B) viral loads, and (C) eAg in animals receiving ETV plus isotype control antibo...
BACKGROUND/AIMS: Immunotherapy of patients chronically-infected with hepatitis B virus (HBV) may hav...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>AIC649 (3.9 x 10<sup>6</sup> Units (ELISA-based titer)) or vehicle were administered i.m. twice w...
<p>Two groups of 5 woodchucks each were treated once daily, orally either with SB 9200 (30 mg/kg/day...
<p>At 66 months post-injection with 100 or 10<sup>10</sup> virions of WHV/tm3 (see <a href="http://w...
<p>Chronic WHV carrier woodchucks were dosed three times a week (TIW) for 15 weeks with placebo, or ...
<p>Changes in serum WHV DNA (top panels) and WHsAg levels (bottom panels) relative to T<sub>0</sub> ...
AIC649 has been shown to directly address the antigen presenting cell arm of the host immune defense...
<p>N/A: not applicable.</p><p><sup>a</sup>Treatment response groups were defined as follows: R, resp...
<p>Serum harvested from early and late infected pups demonstrates significantly higher concentration...
International audienceApolipoprotein A-I (ApoA-I) is the major protein component of high density lip...
<p>(A) Group geometric mean viral loads in acutely infected woodchucks treated with αPD-L1 at 1 or 1...
<p>Change in serum (a) WHsAg and (b) WHV DNA relative to week -3 (pre-treatment baseline). Circles i...
<p>Summary of WHcAg-specific (A) and WHsAg-specific (B) degranulation responses evaluated by CD107a ...
<p>(A) Plasma sAg, (B) viral loads, and (C) eAg in animals receiving ETV plus isotype control antibo...
BACKGROUND/AIMS: Immunotherapy of patients chronically-infected with hepatitis B virus (HBV) may hav...