Pedicled skin flaps exhibit prolonged hypoxia in diabetic db/db mice contrarily to control db/+ mice.

<p>LiPc was implanted in the back of diabetic db/db (n = 14) and non-diabetic db/+ mice (n = 12) (b, c) 7 to 10 days prior to surgery. The pO₂ measurements by EPR oximetry were realized at distal and proximal regions of the flaps. Results are expressed as mean ± SEM (a). *: p <0.05, **: p<0.01 and ***: p<0.001 (One-way ANOVA and Dunnett’s Multiple Comparison post hoc test, comparison with db/+ proximal).