Flueggether A and Virosinine A, Anti-HIV Alkaloids from <i>Flueggea virosa</i>

Two new alkaloids, flueggether A (<b>1</b>) and virosinine A (<b>2</b>), were isolated from a Chinese medicinal plant, <i>Flueggea virosa</i>. Their structures were assigned via spectroscopic methods with the absolute configurations of <b>1</b> and <b>2</b> being established by X-ray diffraction analysis and calculated electronic circular dichroism data, respectively. Compound <b>1</b> represents the first example with an ether bridge of <i>Securinega</i> alkaloid oligomers, and <b>2</b> bears a new heterocyclic backbone. Both alkaloids showed mild in vitro anti-HIV activity