Disease GWAS show substantial genetic overlap with longevity.

<p>Shown are results for coronary artery disease and Alzheimer’s disease. The y axis is the observed P values for longevity[<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005728#pgen.1005728.ref003" target="_blank">3</a>], and the x axis is the expected P values under the null hypothesis that the disease is independent of longevity. The cyan, blue and purple lines show the P values for longevity of the top 100, 250, and 500 disease SNPs from independent genetic loci, respectively. Red lines show the background distribution of longevity P values for all independent genetic loci tested in both the longevity and disease GWAS. The grey horizontal line corresponds to the threshold for nominal significance (P< = 0.05) for longevity. Significance of enrichment was determined with the hypergeometric test. (*) P < 0.05, (**) P < 0.005. Q-Q plots for other diseases and traits are shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005728#pgen.1005728.s002" target="_blank">S1</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005728#pgen.1005728.s003" target="_blank">S2</a> Figs.