TLR4^-/- and TLR2x4^-/-, but not TLR2^-/- mice, display diminished cytokine responses to <i>B</i>.<i>pseudomallei</i> LPS-induced pulmonary inflammation in mice.

<p>mTNF-α (A), interleukin (IL)-6 (B) and KC (C) levels were determined in bronchoalveolair fluid (BALF) of wild-type (WT), TLR2^-/-, TLR4^-/- and TLR2x4^-/- mice 6h post-intranasal administration of 10 ug LPS of <i>B</i>.<i>pseudomallei</i>. Following a Kruskal-Wallis test, Mann-Whitney U-tests were performed. Data are presented as means ± SEM. N = 7 or 9 per group and experiments were performed in duplicate. *** <i>P</i>< 0.001 vs. WT.