Additional file 8: of Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors
- Marie-Laure Golinski (786439)
- Thibault Vandhuick (3441770)
- Céline Derambure (786435)
- Manuel Fréret (786436)
- Matthieu Lecuyer (3441773)
- Clément Guillou (786434)
- Martine Hiron (3441767)
- Olivier Boyer (211211)
- Xavier Le Loët (408285)
- Olivier Vittecoq (408284)
- Thierry Lequerré (786441)
Publication date
December 2015
DOIAbstract
A model of RasGRP1 regulation by TNFα. In T cells, TNFα binding to TNF receptor-1 (TNFR1) leads to a decrease of RasGRP1 protein expression after 48 hours of stimulation. This mechanism prevents mitogen-activated protein kinase activation and induces inhibition of T cell activation and proliferation. We can speculate the establishment of a negative feedback by TNFα to inhibit T cell activation after 48 hours of stimulation, via RasGRP1 inhibition. (TIF 869 kb
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