The presence of antigen stimulates and maintains the cytotoxic capacity of CAR T cells.

<p>The Figure demonstrates cytotoxicity of CAR T cells generated from CLL patients (n = 3) against CD19+ Daudi before (A) and after co-culture with IL-2 (B) and autologous B cells (C). The cytotoxicity was normalized to CAR expression due to variation of expression. Current CAR expression at each specific time-point was used for normalization. Error bars represent SEM.