MRM chromatograms of patients’ plasma samples.

<p>MRM chromatograms of a plasma sample from a patient which have been treated with dabigatran are depicted on the left (A, B, E, F), as well as MRM chromatograms a plasma sample from a patient which have been treated with rivaroxaban are depicted on the right (I, J, M, N). MRM chromatograms of the internal standard [¹³C₆]-dabigatran (C, D, K, L) concerning dabigatran, as well as the internal standard [¹³C₆]-rivaroxaban (G, H, O, P) concerning rivaroxaban are also shown. The first mass transition which was used for quantification of the drug, as well as the second mass transition which was used for verification is plotted. Data were normalized to largest peak in the plots. An estimated peak height is shown in the plots below the transition remark.