Mutual influences of DOAC measurement.

<p>(A) Measurement of rivaroxaban in rivaroxaban and dabigatran spiked plasma. Concentrations were quantified using our UPLC-MRM MS assay (free squares), as well as the automated anti-Xa assay used for rivaroxaban measurement from Chromogenix on the ACL-TOP analyzer (filled circles). For clarification, the measuring points were connected (solid line). The line of identity X = Y is also shown (dotted line). (B) Measurement of dabigatran in rivaroxaban and dabigatran spiked plasma. Concentrations were quantified using our UPLC-MRM MS assay (free squares), as well as the automated DTI assay for dabigatran measurement from CoaChrom Diagnostica performed on the ACL-TOP analyzer. For clarification, the measuring points were connected (solid line). The line of identity X = Y is also shown (dotted line).