Memantine inhibits I₁^PP2A-induced neurodegeneration.

<p>A,B) As compared with AAV1-GFP rats, AAV1-I₁^PP2A rats showed a marked decrease in the expression of somatodendritic marker MAP2 and synaptic markers synapsin and synaptophysin in the hippocampus. Memantine treatment restored dendritic and synaptic loss. B) Western blots showed that β III tubulin staining was significantly decreased in the hippocampus of AAV1-I₁^PP2A rats as compared with AAV1-GFP control animals. Memantine restored the decrease to physiological level. C)Fluoro Jade staining showed a selective neurodegeneration in the AAV1-I₁^PP2A rat dentate gyrus of the hippocampus. Memantine prevented the neurodegeneration in the AAV1-I₁^PP2A rats. 3–4 rats were employed in each experiment. *P<0.05, **P<0.01 AAV1-I₁^PP2A vs. AAV1-GFP rats; ^ΔP<0.05, ^ΔΔP<0.01 AAV1-I₁^PP2A-memantine vs. AAV1-I₁^PP2A-vehicle. Scale bar in A and D, 100 μm.