BR-4628 protects mice from loss of renal function in anti-GBM glomerulonephritis.

<p>(A) Compared to normal control (NC) mice given vehicle (red unfilled squares) or BR-4628 (blue unfilled triangles), urine albumin excretion was massively increased at days 1, 7 and 14 of glomerulonephritis (GN) in mice receiving no treatment (No Tx, black filled circles) or vehicle (red filled squares), and these albuminuria levels were unaffected by treatment with BR-4628 (blue filled triangles). (B) At day 15 of glomerulonephritis, there was a 6-fold increase in serum levels of cystatin-C in mice receiving no treatment or vehicle, which was reduced by 30% in mice treated with BR-4628. Data = mean ± SEM; n = 8. ***p<0.001.