Structural superposition of the reference and final structure of a) FU-nm and b) FU-m are shown as cartoon representation.

<p>In both cases the reference structures are shown in gray while the final structure obtained at the end of 100 ns simulations are shown in red for FU-nm and blue for FU-m. c) Panel highlights two specific regions in the structure that shows maximum deviation in the non-metallated case. The first column shows variation in the SH3 domain, while the second column represents variation in the DNA binding helix [DBH]. Each row in the panel represents the four monomeric subunits.