Dual TCR T cells are not required for initiation of EAE.

<p>EAE was induced in WT and single TCR T cell mice by immunization with 200 μg MOG_35-55 or 50 μg PLP_178-191 plus adjuvant. EAE severity scores were determined daily for up to 21 days post injection. A and B) Average EAE scores of MOG_35-55- and PLP_178-191- induced EAE in WT and single TCR T cell mice over time. Data points are depicted as the mean +/- SEM. One-way ANOVA was used to determine <i>p</i> values (n = 12-15/group). C and D) Percentage of WT or single TCR T cell mice with an EAE score equal to or greater than 1 in MOG_35-55- and PLP_178-191- induced EAE. The <i>p</i> values for Kaplan-Meier curves were calculated using log rank test with Prism software (GraphPad); no significant statistical difference was observed.