The divergence and diversity of simulated sequences in the latent reservoir initially increase much more slowly than in productively infected cells.

<p>After approximately 2 years post-PHI, diversity grows linearly in the latent reservoir (blue solid line) while it starts to saturate in plasma (green solid line). Divergence in the latent reservoir (blue dashed line) grows at approximately the same rate as in the plasma (green dashed line) 6 years post-PHI.