A new coumarin from stem bark of <i>Mesua hexapetala</i>

<p>A new alkylated coumarin derivative, hexapetarin (<b>1</b>) along with three other xanthones, trapezifolixanthone (<b>2</b>), cudraxanthone G (<b>3</b>) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (<b>4</b>), and four common triterpenoids, friedelin <b>(5)</b>, stigmasterol <b>(6)</b>, beta-sitosterol <b>(7)</b> and gamma-sitosterol <b>(8)</b> were isolated from the stem bark of <i>Mesua hexapetala</i> (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (<b>1</b>) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (<b>4</b>) gave very good activity.</p> <p>A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) were isolated from the stem bark of Mesua hexapetala (Clusiaceae). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS.