The R2* maps are derived from the substantia nigra of a representative healthy control and several PD patients with increasing disease duration as given on the upper margin of each image.

<p>Images belong to the same subjects included in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145493#pone.0145493.g005" target="_blank">Fig 5</a>. The white arrows point out increased signals on R2* maps, indicating iron overload. With increasing disease duration the areas of elevated R2* become inhomogeneous.