CNI-1493 significantly reduced metastatic tumor burden.

<p>Mice were treated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145197#pone.0145197.g003" target="_blank">Fig 3</a>. Total cross sectional area of (A) any metastatic tumor, or (B) metastatic tumors demonstrating invasive morphology per tissue section was calculated for each mouse. (C) Primary tumors were excised at the time of animal sacrifice and weighed. Closed symbols represent the animal study replicate with intraperitoneal osmotic pump drug delivery, open symbols represent the animal study replicate with daily intraperitoneal injections. *p<0.05, **p<0.01, bars represent mean ± standard deviation.