ZDF Rat microbiome characterization based on 16S rRNA gene amplicon pyrosequencing.

<p>(A) Histogram of proportional changes in gut microbiota OTU abundance at the L3 level after14 days as measured for treatment cohorts of vehicle (n = 8) and ceftazidime 500 mg/kg (n = 7). DNA sequences are binned by species based on 16S RNA V1-V3 region with 97% identity cut-offs to Greengenes database (as implemented by QIIME software [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145499#pone.0145499.ref031" target="_blank">31</a>]). Principal co-ordinate analysis (PCoA) of β-diversity measures of between-group microbiota community diversity based on treatment with plots of the principal components (PC); (B) PC1vs PC1, (C) PC3 vs. PC2 and, (D) PC1vs PC3.