<p>(A) Sensitivity test on the infection rate <i>k</i>. The value of <i>k</i> increases from 1.44×10<sup>−8</sup> (orange line) to 3.36 ×10<sup>−8</sup> ml virion<sup>-1</sup> day<sup>-1</sup> (black line) with four equal increments. (B) Sensitivity test on the target cell generate rate <i>λ</i>. The value of <i>λ</i> increases from 6000 (orange line) to 14000 cell ml<sup>-1</sup>day<sup>-1</sup> (black line) with four equal increments. (C) Sensitivity test on the viral production rate <i>p</i><sub><i>v</i></sub>. The value of <i>p</i><sub><i>v</i></sub> increases from 15000 (orange line) to 35000 virions cell<sup>-1</sup> day<sup>-1</sup> (black line) with four equal increments. (D) Sensitivity test on <i>γ</i><sub><i>i</i></sub>, the effe...
<p>The system is at steady state and at drug is applied. <b>A, D, G</b> and <b>J</b>: the latent re...
<p>Inflammatory cytokines released during cell death by pyroptosis attract more CD4+ T cells (<i>T</...
<p>Shown are the model compartments. A) Compartment model of the uninfected CD4+ T cell subpopulatio...
<p>(A) CD4+ T cell dynamics predicted by the two-compartment model. (B) Simulation of the model with...
<p>(A) The dynamics of cytokines. The black and brown dashed lines represent two threshold values we...
<p><sup><i>a</i></sup><i>Q</i><sub>0</sub> and <i>S</i><sub>0</sub> are chosen to maintain a stable ...
<p>Key assumed biological parameters in our model were varied in order to test the rigor of the pred...
<div><p>(A) Slow turnover rates for CD4<sup>+</sup> target cells (<i>m</i> = 0.02, <i>k</i> = 0.0005...
<p>(A) CD4+ T cell decline consists of two major phases. A rapid and massive decline is caused by en...
<p>The time evolution of the various singly (solid lines) and doubly (dashed lines) infected cell (l...
<p>Column A: predicted T cell dynamics assuming that CD8 activation is not regulated by CD4+ T cells...
<p>Estimated CD4 cell count dynamics in viremic patients (VIRs: n = 478) and elite controllers (ECs:...
Immune responses rely on a complex adaptive system in which the body and infections interact at mult...
<p>The time evolution of the number of uninfected cells, <i>T</i>, the total number of infected cell...
Immune responses rely on a complex adaptive system in which the body and infections interact at mult...
<p>The system is at steady state and at drug is applied. <b>A, D, G</b> and <b>J</b>: the latent re...
<p>Inflammatory cytokines released during cell death by pyroptosis attract more CD4+ T cells (<i>T</...
<p>Shown are the model compartments. A) Compartment model of the uninfected CD4+ T cell subpopulatio...
<p>(A) CD4+ T cell dynamics predicted by the two-compartment model. (B) Simulation of the model with...
<p>(A) The dynamics of cytokines. The black and brown dashed lines represent two threshold values we...
<p><sup><i>a</i></sup><i>Q</i><sub>0</sub> and <i>S</i><sub>0</sub> are chosen to maintain a stable ...
<p>Key assumed biological parameters in our model were varied in order to test the rigor of the pred...
<div><p>(A) Slow turnover rates for CD4<sup>+</sup> target cells (<i>m</i> = 0.02, <i>k</i> = 0.0005...
<p>(A) CD4+ T cell decline consists of two major phases. A rapid and massive decline is caused by en...
<p>The time evolution of the various singly (solid lines) and doubly (dashed lines) infected cell (l...
<p>Column A: predicted T cell dynamics assuming that CD8 activation is not regulated by CD4+ T cells...
<p>Estimated CD4 cell count dynamics in viremic patients (VIRs: n = 478) and elite controllers (ECs:...
Immune responses rely on a complex adaptive system in which the body and infections interact at mult...
<p>The time evolution of the number of uninfected cells, <i>T</i>, the total number of infected cell...
Immune responses rely on a complex adaptive system in which the body and infections interact at mult...
<p>The system is at steady state and at drug is applied. <b>A, D, G</b> and <b>J</b>: the latent re...
<p>Inflammatory cytokines released during cell death by pyroptosis attract more CD4+ T cells (<i>T</...
<p>Shown are the model compartments. A) Compartment model of the uninfected CD4+ T cell subpopulatio...