sEH gene disruption enhanced I/R-induced tubular damage.

<p>(A): Representative images of PAS-stained sections of kidneys harvested two days after reperfusion or sham surgery (magnification 200×, scale bar: 50 μm). Images were taken at the border of cortex and outer medulla. Arrows indicate necrotic tubules, and asterisks indicate tubular casts. (B): Evaluation of Acute Tubular Necrosis (ATN) score. sEH-KO mice subjected to I/R injury showed significantly increased tubular damage compared to the WT I/R or uninephrectomized control groups. Data are given as mean ± SEM (n = 5 per group). ***p<0.001 vs WT.