The belt region and the loops between secondary structural elements are the most flexible.

<p>Equilibrium simulations were performed using AhR_HIF and AhR_CLOCK models employing GROMOS and CHARMM force fields and discrete molecular dynamics (DMD, 0.53 temperature units). (A, B) Deviation from the starting conformation is characterized by RMSD values. Curves show the average value and colored bands correspond to the standard deviation from 3 independent simulations. (C, D) RMSF is calculated for individual residues for the characterization of protein flexibility.