Modified Method for Measuring the Solubility of Pharmaceutical Compounds in Organic Solvents by Visual Camera

A modified synthetic method with a high definition visual camera technique for measuring the solubility of solutes in solvents or mixed solvents was proposed. To verify the reliability of the experimental apparatus, the solubility of NH₄Cl in water was determined at different temperatures. The relative standard errors were less than 1%, compared to the literature data. The solubilities of betulonic acid in six organic solvents from (278.15 to 313.15) K were measured and correlated with the Apelblat equation and universal quasichemical equation, respectively. The modified method was quite concise and user-friendly, and made the process of dissolution to become visualized and automatic