Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels
- Beekman, Marian
- Heijmans, Bastiaan T.
- Martin, Nicholas G.
- Whitfield, John B.
- Pedersen, Nancy L.
- DeFaire, Ulf
- Snieder, Harold
- Lakenberg, Nico
- Knijff, Peter
- Frants, Rune R.
- van Ommen, Gert Jan B.
- Kluft, Cornelis
- Vogler, George R.
- Slagboom, P. Eline
- Boomsma, Dorret I.
Publication date
January 2003
DOI Publisher
Cambridge University Press (CUP)Abstract
Plasma levels of lipoprotein(a) _ Lp(a) _ are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs
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