Input/output relations arising from the combination of the subthreshold activity and the short-term depression of a dynamic synapse.

<p>Panels display input/output activity maps showing the mean subthreshold oscillation frequency (left column) and the mean output spiking frequency (right column) for different depression levels. #<i>spikes</i> and <i>f</i>_<i>d</i> denote the number of spikes per burst and the intraburst stimulation frequency, respectively. (A) Neuron’s response to an input delivered through the dynamic synapse as a function of parameters <i>τ</i>_<i>rec</i> and <math><mi>U</mi></math> which set the depression level. In these maps, <i>x</i>-axis ranges from 0.02<i>ms</i> to 800<i>ms</i> with a step of 100<i>ms</i>, and <i>y</i>-axis ranges from 0.05 to 0.35 at intervals of 0.05. (B-C) Input/output relations dependence on the intraburst stimulation frequency. Maps are built with a fixed value of <math><mi>U</mi></math> and for different stimulation frequencies delivered through the dynamic synapse (<i>y</i>-axes in these panels, with <i>f</i>_<i>d</i> ranging from 5<i>Hz</i> to 50<i>Hz</i> at intervals of 5<i>Hz</i>). Yellow, green and red dashed-rectangles in maps shown in panel C indicate the regions analyzed in detail in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145830#pone.0145830.g004" target="_blank">4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145830#pone.0145830.g005" target="_blank">5</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0145830#pone.0145830.g006" target="_blank">6</a>, respectively.