(A) Lung expression of 11β-HSD1, (B) of 11β-HSD2 and (C) the ratio 11β-HSD1/11β-HSD2 (C).

<p>The expression of 11β-HSD1 only showed a not significant increase induced by pancreatitis in <i>cbg</i>^<i>+/+</i> female. In contrast, pancreatitis decreased in both genders the expression of 11β-HSD2. <i>Cbg</i>^<i>-/-</i> mice showed lower expression of 11β-HSD2. The ratio 11β-HSD1/11β-HSD2 was increased by pancreatitis in all groups studied but only significantly in females for both genotypes. Two Way Anova: Lung expression of 11β-HSD1: Treatment P = 0.2238, Sex P = 3996, Interaction P = 5188; Lung expression of 11β-HSD2: Treatment P<0.0001, Sex P = 0.0012, Interaction P = 0.0057; ratio11β-HSD1/11β-HSD2: Treatment P<0.0001, Sex P = 0.1818, Interaction P = 0.7634; Bonferroni Post test: * P<0.05 control vs pancreatitis; + P<0.05 male vs female; • P<0.05 <i>cbg</i>^<i>+/+</i> vs <i>cbg</i>^<i>-/-</i>.