Antigen-induced arthritis in mice is mainly associated with the presence of neutrophils.

<p>(A) Intensity of nociception. (B) Number of neutrophils, (C) myeloperoxidase activity, and (D) CXCL1 chemokine levels in the peri-articular tissue. (E) Representative photos of the morphologic alterations in the knee (x100 and x400) and (F) arthritis index. Arrows indicate the synovial and asterisks represent the inflammatory infiltrate. Adipose tissue and liver (G) myeloperoxidase activity, and (H) CXCL1 levels at 1, 3, 24 and 48 hours after the challenge with the antigen-induced arthritis (AIA). Bars represent the mean values±SEM (n = 6–8). Neutrophils number in (I) epididymal adipose tissue and liver accumulated in Lysm-eGFP mice and (J) representative confocal microscopy image, 3 and 24 hours after the challenge with the AIA (x100). Bars represent the mean values±SEM (n = 3–5), *<i>P</i><0.05 vs. PBS.