Depletion of neutrophils did not improve the metabolic alterations in antigen-induced arthritis mice.

<p>(A) Intensity of nociception. Inflammation in the knee cavity represented by (B) number of neutrophils and (C) myeloperoxidase activity. Metabolic features represented by (D) glucose, (E) triglyceride and total cholesterol levels, accompanied by the adipocytokines (F) adiponectin and leptin levels in the serum. (G) The PTX3 of mice that received an intra-articular injection in the knee cavity of PBS, mBSA or mBSA treated prior with RB6-8C5. The bars represent the mean values±SEM (n = 4–6), *<i>P</i><0.05 vs. PBS; #<i>P</i><0.05 vs. AIA of the respective time.