Pre-treatment with Etanercept improves the altered metabolic parameters of antigen-induced arthritis mice.

<p>(A) Intensity of nociception. (B) Neutrophils, (C) myeloperoxidase activity, (D) CXCL1 chemokine in the peri-articular tissue and (E) arthritis index. Systemic glucose metabolism showed by (F) glucose levels, (G) HOMA-IR index and (H) oral glucose tolerance test. The lipids, (I) triglyceride and total cholesterol levels. The adipocytokines, (J) adiponectin and leptin levels. (K) PTX3 levels of mice that received a knee intra-articular injection of PBS, mBSA or mBSA treated prior with Etanercept. Bars represent the mean values ±SEM (n = 6–8), *<i>P</i><0.05 vs. PBS; #<i>P</i><0.05 vs. AIA of the respective time.