<p>(A-F) Representative images of sections through the anterior (A, B), middle (C, D) and posterior (E, F) regions of the palate in wildtype (A, C, E) and <i>Foxf2</i><sup><i>-/-</i></sup> mutant (B, D, F) embryos showing distribution of immunostained BrdU-labeled nuclei (green). Sections were counterstained with DAPI (blue). White line divides the palatal shelf into oral and nasal sides for cell counts. (G) The percentage of BrdU-labeled cells in the E13.5 palatal mesenchyme (***p<0.001). AO, oral half of the anterior region; AN, nasal half of the anterior region; MO, Oral half of the middle region; MN, nasal half of the middle region; PO, oral half of the posterior region; PN, nasal half of the posterior region.</p
Objectives: Hard palate development occurs between 7-12 weeks post conception with the fusion of the...
<p>(A) In situ hybridization detects <i>Col II</i> expression in the Meckel's cartilage but not in t...
The aim of this study was to re-evaluate the classical description of fusion as the closure mechanis...
<p><b>A–E</b>, frontal sections at E14.5 of control (A) and of several mutant embryos (B–E) showing ...
<p>(A-D) Whole-mount <i>in situ</i> hybridization detection of <i>Foxf1</i> (A, C) and <i>Foxf2</i> ...
<p>(A, B) The patterns of RFP expression in the <i>Osr2</i><sup><i>RFP/+</i></sup> (A) and <i>Foxf2<...
<p>(A) Coronal sections from the middle region of the palate at E13.5-E15.5. Whereas the palatal she...
<p>At E15.5, palatal fusion was well under way in the wild-type embryo (+/+) (A, C, E, G). <i>Ceacam...
<p>At E18.5 the palate has fused completely in all wildtype foetuses (A) but a proportion of <i>Fras...
<p>(A–H) Coronal sections show BrdU-labeled cells in the palatal shelves of E12.5 (A–D) and E13.5 (E...
Orofacial clefts are the most common birth defect worldwide. One key component of craniofacial devel...
<p>(A, B, E, F) Expression patterns of <i>Shh</i> mRNAs in the developing palatal shelves in wildtyp...
In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the anteropos...
<p>(A) Ventral views of palates from <i>Bmp7<sup>wt/wt</sup></i>, <i>Bmp7<sup>Δ/Δ</sup>, Bmp7<sup>fl...
<p>Ventral view of upper jaw explants from E13.5 <i>Bmp7<sup>wt/lacZ</sup></i> control (A, C, E) or ...
Objectives: Hard palate development occurs between 7-12 weeks post conception with the fusion of the...
<p>(A) In situ hybridization detects <i>Col II</i> expression in the Meckel's cartilage but not in t...
The aim of this study was to re-evaluate the classical description of fusion as the closure mechanis...
<p><b>A–E</b>, frontal sections at E14.5 of control (A) and of several mutant embryos (B–E) showing ...
<p>(A-D) Whole-mount <i>in situ</i> hybridization detection of <i>Foxf1</i> (A, C) and <i>Foxf2</i> ...
<p>(A, B) The patterns of RFP expression in the <i>Osr2</i><sup><i>RFP/+</i></sup> (A) and <i>Foxf2<...
<p>(A) Coronal sections from the middle region of the palate at E13.5-E15.5. Whereas the palatal she...
<p>At E15.5, palatal fusion was well under way in the wild-type embryo (+/+) (A, C, E, G). <i>Ceacam...
<p>At E18.5 the palate has fused completely in all wildtype foetuses (A) but a proportion of <i>Fras...
<p>(A–H) Coronal sections show BrdU-labeled cells in the palatal shelves of E12.5 (A–D) and E13.5 (E...
Orofacial clefts are the most common birth defect worldwide. One key component of craniofacial devel...
<p>(A, B, E, F) Expression patterns of <i>Shh</i> mRNAs in the developing palatal shelves in wildtyp...
In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the anteropos...
<p>(A) Ventral views of palates from <i>Bmp7<sup>wt/wt</sup></i>, <i>Bmp7<sup>Δ/Δ</sup>, Bmp7<sup>fl...
<p>Ventral view of upper jaw explants from E13.5 <i>Bmp7<sup>wt/lacZ</sup></i> control (A, C, E) or ...
Objectives: Hard palate development occurs between 7-12 weeks post conception with the fusion of the...
<p>(A) In situ hybridization detects <i>Col II</i> expression in the Meckel's cartilage but not in t...
The aim of this study was to re-evaluate the classical description of fusion as the closure mechanis...