Comparison of expression of <i>Fgf18</i> and <i>Shh</i> mRNAs in the palatal shelves in <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i> control and <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i><i>Wnt1-Cre</i> mutant embryos.

<p>(A, B) Whole-mount <i>in situ</i> hybridization detection of <i>Fgf18</i> mRNAs in the developing palatal shelves in <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i> control (A, C) and <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i><i>Wnt1-Cre</i> mutant (B, D) embryos at E12.5 (A, B) and E13.5 (C, D). White dashes demarcate the palatal shelf on the right side. Arrowhead (A, C) and arrow (B, D) point to the <i>Fgf18</i> expression domains in the control and mutant palatal shelves, respectively. (E, F) Whole-mount <i>in situ</i> hybridization detection of <i>Shh</i> mRNAs in the developing palatal shelves in <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i> control (E) and <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i><i>Wnt1-Cre</i> mutant (F) embryos at E13.5. Note that expression of <i>Shh</i> is lost in <i>Foxf1</i>^<i>c/c</i><i>Foxf2</i>^<i>c/c</i><i>Wnt1-Cre</i> mutant palatal shelves.