Rv1410 function is necessary for growth of <i>Mtb</i> in mice with immune deficiencies, indicating that loss of virulence is intrinsic to the bacterium.
- Amanda J. Martinot (398601)
- Mary Farrow (844849)
- Lu Bai (343118)
- Emilie Layre (158038)
- Tan-Yun Cheng (158033)
- Jennifer H. Tsai (844850)
- Jahangir Iqbal (844851)
- John W. Annand (844852)
- Zuri A. Sullivan (504188)
- M. Mahmood Hussain (844853)
- James Sacchettini (206943)
- D. Branch Moody (158059)
- Jessica C. Seeliger (187377)
- Eric J. Rubin (132597)
Publication date
January 2016
DOIAbstract
<p>Colony forming units (cfu) of WT (H37Rv, black) and <i>rv1410</i>::Tn (Mut1, red) from spleen and lungs of mice infected with a 3:1 (Mut1:WT) mixture. (A) C57/Bl6 (B) <i>nos2-/-</i> (C) <i>phox-/-</i> (D) <i>phox-/-</i> fed aminoguanidine <i>ad libitum</i>, and (E) <i>inf-γ -/-</i> mice. Cfu were measured in lung and spleen at 1, 7, and 30 days post infection. Error bars show mean +/- SD of three to five animals per time point.</p
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