Glucose inhibits proliferation of cells deleted of mtDNA.

<p>(A) Decreasing glucose concentration leads to increased proliferation of cells lacking mtDNA. Strain BY4742 (<i>WT</i>) was cultured in YEPD medium containing 2%, 0.5%, or 0.2% glucose and tested for the response to mtDNA deletion. Cells were incubated for 3 d. (B) Proliferation of <i>ρ</i>^<i>0</i> cells by Gpa2p or Gpr1p deletion is not improved further upon lowering the glucose concentration. Strains BY4742 (<i>WT</i>), CDD849 (<i>gpa2Δ</i>), and CDD850 (<i>gpr1Δ</i>) were treated as in (A), yet incubated on solid medium for 2 d.