Tumor growth by motility phenotypes.

<p>Virtual magnetic resonance imaging of simulations of untreated tumor growth in highly-dispersive tumors (a and b), moderately-dispersive tumors (c and d), and hypoxia-driven tumors (e and f). In each simulation, the first time shot (diagnosis) is identical to the first time shot for the treated tumors in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146617#pone.0146617.g003" target="_blank">Fig 3</a>, the second time shot shows first follow-up (1 or 2 months), and the final time shot displays tumor appearance at death. The percents of the brain with 80% or more necrosis at time of death are: 0.7% (a and b), 3.0% (c), 4.1% (e), 4.3% (d and f). Percents of brain with the presence of high density tumor at time of death are: 15% (a and b), 5% (c), 6% (d), and less than 0.3% (e and f). The corresponding parameter choices for hypoxia-driven and concentration-driven may be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146617#pone.0146617.t004" target="_blank">Table 4</a>. P, I, and B refer to the proliferative, invasive, and brain cells, respectively.