Chemoresistant H1650 SP cells are sensitized to Cisplatin by Nos_SESDs and Mann-Nos_SESDs.

<p>(a) H1650 SP cells showed higher spheroid formation potential compared to H1650 MP cells (***P<0.0001). (b-d) Anticancer effects of Noscapine (Nos) and Cisplatin (Cis) determined by cell viability studies in (b) H460, (c) H1650 MP, and (d) H1650 SP cells after 72 hr incubation; single and combination treatments of Cis, Nos, and Cis with fixed concentrations (5, 10, and 20 μM) of Nos after 72 hr incubation demonstrated no significant anticancer effects. (e) The marginal decreases in H1650 SP cell viability following treatment with Nos_SESDs and Mann-Nos_SESDs are significantly enhanced when giving in combination with Cis. Results were presented as cell viability (percent of control) against log concentration as triplicates of at least two different experiments.