1. Pirfenidone, an antifibrotic compound with anti-inflammatory effects, has been investigated in a rat model of acute experimental ischaemia-reperfusion injury of the small intestine. 2. Occlusion of the superior mesenteric artery in young adult female rats for 30 min followed by reperfusion for 120 min induced significant local and systemic effects, including tissue haemorrhage with oedema, elevated serum concentrations of tumour necrosis factor (TNF)-α, neutropenia, hypotension and bradycardia. 3. Administration of pirfenidone (200 mg/kg, p.o., i.v. or i.p.) 30 min before occlusion completely inhibited the increase in serum TNF-α concentrations. Pirfenidone inhibited, but did not completely prevent, tissue damage in the small intestine, ...
Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response. No ideal...
Background: Spironolactone (Sp), a mineralocorticoid receptor antagonist, protects against the ische...
Pirfenidone is an antifibrotic drug that we have shown attenuates the increase in collagen buildup i...
Background Accidental ingestion of caustic substances induces esophageal injuries and stenosis forma...
PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and ti...
Aim. Occlusion and reperfusion of splanchnic arteries cause local and systemic changes due to the re...
Aim The aim of this study is to investigate the effects of sulforaphane (SFN), which has been shown ...
Myocardial fibrosis is an endogenous response to different cardiac insults that may become maladapti...
In this study, we evaluated the effect of tyrphostin AG126, a tyrosine kinase inhibitor, in the spla...
Aim. Occlusion and reperfusion of splanchnic arteries cause local and systemic changes due to the re...
1 This study has administered pirfenidone (5-methyl-l-phenyl-2-[1H]-pyridone) or amiloride to attenu...
Myocardial fibrosis is a common feature of several heart diseases. The progressive deposition of ext...
Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. ...
Background: Pirfenidone (PF) is a potent antifibrotic and anti-inflammatory agent. We investigated t...
Pirfenidone is an orally active small molecule that has recently been evaluated in large clinical tr...
Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response. No ideal...
Background: Spironolactone (Sp), a mineralocorticoid receptor antagonist, protects against the ische...
Pirfenidone is an antifibrotic drug that we have shown attenuates the increase in collagen buildup i...
Background Accidental ingestion of caustic substances induces esophageal injuries and stenosis forma...
PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and ti...
Aim. Occlusion and reperfusion of splanchnic arteries cause local and systemic changes due to the re...
Aim The aim of this study is to investigate the effects of sulforaphane (SFN), which has been shown ...
Myocardial fibrosis is an endogenous response to different cardiac insults that may become maladapti...
In this study, we evaluated the effect of tyrphostin AG126, a tyrosine kinase inhibitor, in the spla...
Aim. Occlusion and reperfusion of splanchnic arteries cause local and systemic changes due to the re...
1 This study has administered pirfenidone (5-methyl-l-phenyl-2-[1H]-pyridone) or amiloride to attenu...
Myocardial fibrosis is a common feature of several heart diseases. The progressive deposition of ext...
Background: Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. ...
Background: Pirfenidone (PF) is a potent antifibrotic and anti-inflammatory agent. We investigated t...
Pirfenidone is an orally active small molecule that has recently been evaluated in large clinical tr...
Ischemia/reperfusion (I/R) is a condition that stimulates an intense inflammatory response. No ideal...
Background: Spironolactone (Sp), a mineralocorticoid receptor antagonist, protects against the ische...
Pirfenidone is an antifibrotic drug that we have shown attenuates the increase in collagen buildup i...