Short- and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney
- Xiaowen Liang (373131)
- Haolu Wang (741306)
- Yian Zhu (1423144)
- Run Zhang (504646)
- Victoria C. Cogger (1423141)
- Xin Liu (43569)
- Zhi Ping Xu (1394215)
- Jeffrey E. Grice (600032)
- Michael S. Roberts (250320)
DOIAbstract
While biodistribution of nanoparticles (NPs) has been widely studied at the organ level, relatively little is known about their disposition in organs at the cellular level, especially after long-term exposure. The kidney is regarded as the key organ for the clearance of ultrasmall NPs (<5.5 nm). However, recent studies indicate that NPs in this size range could accumulate in the kidney for extended times without urinary excretion. Using negatively charged quantum dots (QDs) (∼3.7 nm) as a model system, we examined the suborgan disposition of anionic ultrasmall NPs in the kidney at the cellular level after intravenous injection by multiphoton microscopy coupled with fluorescence lifetime imaging. Most of the NPs were initially distributed in...
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