Cobalt-Catalyzed Benzylic Borylation: Enabling Polyborylation and Functionalization of Remote, Unactivated C(sp³)–H Bonds

Cobalt dialkyl and bis­(carboxylate) complexes bearing α-diimine ligands have been synthesized and demonstrated as active for the C­(sp³)-H borylation of a range of substituted alkyl arenes using B₂Pin₂ (Pin = pinacolate) as the boron source. At longer reaction times, rare examples of polyborylation were observed, and in the case of toluene, all three benzylic C-H positions were functionalized. Coupling benzylic C-H activation with alkyl isomerization enabled a base-metal-catalyzed method for the borylation of remote, unactivated C­(sp³)-H bonds