Dot blot analyses using species-specific antibodies. Preparation of Aβ contains both oligomeric and fibrillar Aβ. Immunoreactivity of dot blots of Aβ scrambled (Aβscr) or Aβ1-42 was detected using 4G8, A11, or OC antibodies as described in the “Methods” section. Scrambled Aβ demonstrates antibody specificity. (PDF 155 KB
Figure S1. Widespread brain expression of human αS in M20+/−and M83+/− mice. Immunohistochemistry sh...
Supplemental Figures. Figure S1. Hierarchical clustering of proteins differentially expressed (p<0.0...
Figure S1. Microglia isolation from adult mouse brain and validation by q-RT-PCR and FACS analysis. ...
Figure S1. Analysis of APP levels in uninoculated AppNL-F mice. a Immunoblots of brain homogenates f...
Aβ plaque onset age in 5XFAD/apoEm/m and 5XFAD/apoE4/4 brain. Aβ immunostaining was performed using ...
Figure S2. Expression of TLR2 in microglia. Microglia were prepared and treated as described in the ...
Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically ...
Table S1. Affinity of SAR228810 and SAR255952 for the respective FcγRs. Table S2. SAR255952 prevents...
List of primary antibodies used in immunohistochemistry (IHC) and western blot (WB). (DOCX 28 kb
Specific antibodies for mouse apoE and human apoE4 immunostaining. 5XFAD/apoEm/m and 5XFAD/apoE4/4 b...
Immunostainings with Aβ42 specific antibodies confirm Aβ42 protofibril inclusions in astrocytes. Aft...
The mAb1C3 lowers Aβ inclusions in astrocytes. Aβ42 protofibrils were accumulated in astrocytes (A),...
The heavy and light chain of the mAb158 antibody can be detected in the media. Reprobing the filter ...
Immunostaining against Aβ and GPNMB in parallel sections in the cortex of a 12-month-old APP23 mouse...
Figure S3. Validation of astrocyte sorting. Normalized expression of cell type specific genes. GFP+ ...
Figure S1. Widespread brain expression of human αS in M20+/−and M83+/− mice. Immunohistochemistry sh...
Supplemental Figures. Figure S1. Hierarchical clustering of proteins differentially expressed (p<0.0...
Figure S1. Microglia isolation from adult mouse brain and validation by q-RT-PCR and FACS analysis. ...
Figure S1. Analysis of APP levels in uninoculated AppNL-F mice. a Immunoblots of brain homogenates f...
Aβ plaque onset age in 5XFAD/apoEm/m and 5XFAD/apoE4/4 brain. Aβ immunostaining was performed using ...
Figure S2. Expression of TLR2 in microglia. Microglia were prepared and treated as described in the ...
Figure S1. Oligomeric Aβ1–42 specifically binds to TREM2. Figure S2. Oligomeric Aβ1–42 specifically ...
Table S1. Affinity of SAR228810 and SAR255952 for the respective FcγRs. Table S2. SAR255952 prevents...
List of primary antibodies used in immunohistochemistry (IHC) and western blot (WB). (DOCX 28 kb
Specific antibodies for mouse apoE and human apoE4 immunostaining. 5XFAD/apoEm/m and 5XFAD/apoE4/4 b...
Immunostainings with Aβ42 specific antibodies confirm Aβ42 protofibril inclusions in astrocytes. Aft...
The mAb1C3 lowers Aβ inclusions in astrocytes. Aβ42 protofibrils were accumulated in astrocytes (A),...
The heavy and light chain of the mAb158 antibody can be detected in the media. Reprobing the filter ...
Immunostaining against Aβ and GPNMB in parallel sections in the cortex of a 12-month-old APP23 mouse...
Figure S3. Validation of astrocyte sorting. Normalized expression of cell type specific genes. GFP+ ...
Figure S1. Widespread brain expression of human αS in M20+/−and M83+/− mice. Immunohistochemistry sh...
Supplemental Figures. Figure S1. Hierarchical clustering of proteins differentially expressed (p<0.0...
Figure S1. Microglia isolation from adult mouse brain and validation by q-RT-PCR and FACS analysis. ...