Additional file 4: Figure S3. of p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer

p53 silencing increases growth at metastatic sites. BC3-p53WT or BC3-p53KD cells were injected to the left cardiac ventricle (A, p = 0.22 at 4 weeks; p = 0.01 at 6 weeks)) or tail vein (B, p = 0.03 at 13 weeks), and mice were subjected to BLI in vivo at the indicated time points. Total photon flux was assessed on an IVIS SPECTRUM and quantified. Each data point represents one mouse. All error bars represent standard error of the mean (SEM). Wilcoxon rank sum tests were used for statistical analyses. (PDF 73 kb