<p>Simulated interactions for (A) FBA-ko and (B) for FBA-div, in selected metabolic pathways. More complete simulation results are shown elsewhere (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0147651#pone.0147651.s006" target="_blank">S2</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0147651#pone.0147651.s008" target="_blank">S4</a> Figs). Each symbol represents the simulated response to inhibiting a single or pair of targets (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0147651#pone.0147651.g002" target="_blank">Fig 2</a>), with enzymes organized by pathway and metabolic reaction order in the iAF1260 model. Symbol shape shows the type of epistasis (synthetic ...
<p>The dotted box includes the interactions considered in the model. Solid arrows indicate chemical ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
<p>(A) Known anti-metabolism drug synergies. Locating the iAF1260 model enzymes in the KEGG E. coli ...
Background: The study of biological interaction networks is a central theme of systems biology. Here...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
Purpose: Modeling metabolic interactions between chemicals can be a formidable model development tas...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
<p>The dotted box includes the interactions considered in the model. Solid arrows indicate chemical ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
<p>(A) Known anti-metabolism drug synergies. Locating the iAF1260 model enzymes in the KEGG E. coli ...
Background: The study of biological interaction networks is a central theme of systems biology. Here...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
Purpose: Modeling metabolic interactions between chemicals can be a formidable model development tas...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
Background: Metabolic flexibility is the ability of an organism to switch between substrates for ene...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
We have witnessed an explosive growth in research involving mathematical models and computer simula...
<p>The dotted box includes the interactions considered in the model. Solid arrows indicate chemical ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...
Metabolic channelling occurs when two enzymes that act on a common substrate pass that intermediate ...