Additional file 2: of Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

Time-lapse recordings demonstrating the lack of the intravascular rolling and adhesion of leukocytes in C3 −/− mice after intraventricular LPS injection (4 h). Rolling leukocytes were defined as those cells moving at a velocity less than that of erythrocytes. Cells were considered adherent if they remained stationary for at least 30 s in a distance of 100 μm. (MOV 750 kb