Metabolic Effect of 5HT on a High Fat Diet.

<p>A, The concentrations of blood NEFA, cholesterol, triglyceride, glucose, insulin, leptin and adiponectin were measured in mice aged between 21 and 26 weeks of age (n = 7–12). B and C, Glucose tolerance (B) and insulin tolerance (C) tests were performed in each group of mice at 21 weeks of age (n = 7). Circles, Ch+PBS; filled circles, Ch+5HT; squares, F+PBS; filled squares, F+5HT. Data are means ± s.e. Data in (A) were analyzed by two-way ANOVA. Data in (B) and (C) were analyzed by Student's t test. Columns with a different letter are significantly different (p<0.05). *p<0.05, **p<0.01 indicates significance in F+5HT mice against F+PBS mice.