Differential shortening/lengthening of k-fibers during anaphase can lead to segregation of the bridged chromosomes to the same daughter cell.

<p>(A-C) Diagram illustrating how differential shortening/lengthening of k-fibers during anaphase would lead to segregation of the bridged chromosomes to the same daughter cell. Depending on the extent of the length differential between the two k-fibers bound to the bridge kinetochores, the bridged chromosome may end up in the main nucleus (B) or in a micronucleus (C). (D-E) Example of vHMEC in which the bridged chromosomes are segregating to the same daughter cell. DNA is shown in blue, kinetochores (KTs, immunostained using CREST antibodies) in green, and microtubules (MTs) in red. Open arrowheads point to the two ends/KTs of the chromosome bridge. Note that the cleavage furrow (arrows) is ingressing on one side of the chromosome bridge, thus pushing the whole bridge into one of the daughter cells. Scale bar, 5 μm.