Peptide Vaccine is Rendered Therapeutically Effective if Repetitive Delivery is Continued Post Tumor Challenge.
- Vani Lakshminarayanan (846891)
- Nitin T. Supekar (846892)
- Jie Wei (264772)
- Dustin B. McCurry (846893)
- Amylou C. Dueck (289612)
- Heidi E. Kosiorek (846894)
- Priyanka P. Trivedi (846895)
- Judy M. Bradley (625966)
- Cathy S. Madsen (846896)
- Latha B. Pathangey (846897)
- Dominique B. Hoelzinger (846898)
- Margreet A. Wolfert (846899)
- Geert-Jan Boons (212062)
- Peter A. Cohen (285698)
- Sandra J. Gendler (846900)
Publication date
January 2016
DOIAbstract
<p>MUC1.Tg mice were given two peptide immunizations before and two after tumor challenges. Three out of four peptide vaccinations significantly delayed the growth of B16.MUC1 tumors (APG+SAP 9mer, p = 0.001; APG+SAP Tn-9mer, p = 0.001; SAP 22mer, p = 0.001) and <b>(B)</b> showed complete protection in 4 out of 10 mice (SAP 22mer) and 3 out of 10 mice (9mers and Tn-9mers), if immunizations were continued post tumor challenges. Experiment was repeated 2 times, n = 5 mice/group.</p
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