Cre+DTA+ mice tested less than or more than 4 weeks post-TAM show similar levels of locomotion and the absence of baseline anxiety-related behaviors.

<p><b>(A, B)</b> Locomotor activity (LM) in both short (<b>A,</b> Group 1, control N = 8, Cre+DTA+ N = 5) and long (<b>B,</b> Group 2, control N = 33, Cre+DTA+ N = 13) TAM-beh interval groups. Insets <b>A, B</b>: total beam breaks over 2 hr. Main panels <b>A, B</b>: beam breaks over 2 hr presented in 5 min bins. X axis * = main effect of time. Posthoc analysis (Bonferroni) revealed all points in main panels were significantly different than the initial locomotor activity data point. However, individual data point asterisks are omitted for clarity, as there was no main effect of genotype or interaction of time X genotype for either Group 1 or Group 2. <b>(C-F)</b> Time spent in the center <b>(C, E)</b> and periphery <b>(D, F)</b> during an open field test (OF) in short (<b>C-D,</b> Group 1, control N = 30, Cre+DTA+ N = 9) and long (<b>E-F,</b> Group 2, control N = 42, Cre+DTA+ N = 17) TAM-beh interval groups. <b>(G-J)</b> Number of transitions between light and dark chambers <b>(G, I)</b> and latency to enter the dark chamber <b>(H, J)</b> in the light/dark test (L/D test) in both short (<b>G-H,</b> Group 1, control N = 30, Cre+DTA+ N = 9) and long (<b>H-I,</b> Group 2, control N = 38, Cre+DTA+ N = 17) TAM-beh groups. Data are mean±SEM. ^<i>d</i>p<0.0001, two-way ANOVA with repeated measures and Bonferroni posthoc <b>(A, B)</b>. *p<0.05, unpaired two-tailed Student’s t-test (<b>insets A, B,</b> and <b>C-H</b>).