Histological analysis finds evidence of fibrosis and hypertrophy in the BACHD hearts.

<p>Examples of Masson’s Trichrome stained heart sections from 15 mo old WT and BACHD mice (A). Quantification of fibrosis by measuring the integrated density of fibrotic tissue and divided by tissue area detected significantly increased areas of fibrosis in BACHD mice (B). Examples of hematoxylin and eosin (H&E) stained heart sections from 15 mo old WT and BACHD mice (C). Morphometry measurements comparing heart weight relative to body weight between 15 mo old WT and BACHD mice (D). * <i>P</i><0.05 for genotypic differences.