T cells in human skin are transcriptionally distinct from skin-tropic T cells in the blood.

<p>Principal component analysis of gene expression of sorted skin and blood CD4⁺, CD8⁺ and regulatory T cells. Graphs plotted showing (a) principal components 1,2 and 3 and (b) principal components 18 and 21. Each symbol represents one array; 5 arrays/cell type. (c) Venn diagram showing overlap of the significantly differentially expressed genes (DEGs, listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0148351#pone.0148351.s005" target="_blank">S3 Table</a>; P≤0.05) in pairwise comparison between skin and blood CD4⁺, CD8⁺ and regulatory T cells using RUVinv analysis. (d) Venn diagram of DEGs between T cell lineages in blood and skin (listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0148351#pone.0148351.s006" target="_blank">S4 Table</a>; P≤0.05) showing overlaps between categories. Numbers in brackets indicate total number of DEGs from each pairwise comparison. Treg, regulatory T cells.