Oral Administration of Polymyxin B Modulates the Activity of Lipooligosaccharide <i>E</i>. <i>coli</i> B against Lung Metastases in Murine Tumor Models - Fig 8

<p>A. Mice treatment schedule. An administration of polymyxin B (7.38 mg/250 ml in drinking water) was started on the 5^th day before the i.v. injection of 3x10⁵ LLC cells and continued throughout the experiment duration. Mice were injected with LOS (1μg/mouse) i.p. one hour before cell injection. On the 15^th day after injection, material were harvested and number of lung metastases was determined. B. Number of the LLC metastasis in the lung obtained from treated mice on the 15^th day of experiment. To calculate the mean, 10–11 mice of each group of two experiments were tested. The relationship between groups was calculated for n>11 using Mann-Whitney <i>U</i> test. differences with a p<0.01 were regarded as significant (**p<0.01—calculated vs untreated mice).