Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and <i>N</i>‑Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive

A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and <i>N</i>-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd­(dba)₂ is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with <i>N</i>-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol